Castelletto Uzzone is a comune (municipality) in the Province of Cuneo in the Italian region of Piedmont and is located about 70 km southeast of Turin and about 50 km east of Cuneo. As of 31 December 2004, it had a population of 364 and an area of 15.1 km2.
Castelletto Uzzone borders the following municipalities: Dego, Gottasecca, Levice, Pezzolo Valle Uzzone, Piana Crixia, and Prunetto.
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